The simple fact is that there are only two brands which will reliably work out of the box. USFA and Ruger. All the rest, INCLUDING Colt's, need an action job first, to properly fit the internals and prevent them self destructing. All the Ubertis, be they Navy, Cimarron, Taylors, or Berettas; and all the Piettas, including the Great Western II, fall into that category. Ruger and USFA will still benefit from action work, but will survive without it. The rest will benefit from it, but tear themselves apart without it.
If action work is a given, then the choice comes down to whether you prefer transfer bar or original style action work. With a transfer bar, you can carry all six chambers loaded, without one, safety requires the gun be carried hammer down on an empty chamber.
That established, the next choice is based on the quality of the metallurgy. In the original style, Colt's and USFA rank about even, with the Italian stuff being about like warm butter by comparison. In the transfer bar stuff, Colt's cowboy is probably number one, but hard to find. Ruger is fairly close behind.
On the other hand, one does have to pay for that hard steel, as the Colt's and USFA run about double the price of the Italian guns. Ruger definitely wins the bang for the buck competition.
~~~Mat