Charles Newton, who designed the .250-3000 for Savage, is usually credited with being the first to neck down the cartridge for the .248" bullet in the late 1920's. Later, in the 1930's, other wildcatters increased shoulder angle to 28 degrees and loaded the cartridge with .224" bullets. One of those wildcatters was gunsmith Jerry Gebby. For those who wanted a ".22 varminter," as Gebby called it, but didn't handload, custom loads were available from J. Bushnell Smith.
Prior to the introduction of the .222 Remington family of cartridges, the .22-250 enjoyed greater popularity than any other varmint cartridge. All of which makes one wonder why it took Remington until 1965 to domesticate the cartridge. Even today the .22-250 is only second only to the .223 Remington is popularity among varmint shooters.
The first factory rifle available in the .22-250 (even before factory loads were available) was the Browning. Remington followed with the Model 700 and now every rifle maker , big and small, offers this chambering. Many serious varmint shooters consider the Remington 40X to be the most accurate factory made .22-250 available since it is capable of placing five bullets into less than 1/2" MOA.
For long range varmint shooting, the .22-250 is an outstanding cartridge and when chambering in a top quality rifle is capable of superb accuracy. The hollow point bullets are fine for punching paper with this cartridge but some don't expand at extremely long range as well as soft point bullets. When all is said and done, the .22-250 is seen at its best when loaded with a 55 grain spitzer. H380 is an outstanding powder for the .22-250. Other propellants worthy of a try are IMR-4064