Sig Trailside. Period.
Unless you're going high-end Olympic; then you'll want a real Hammerli or a Pardini, or perhaps a custom 1911 bottom end with a Marvel top end.
I've shot all the Rugers (Mark II's and III's with all kinds of barrel variations), P22, S&W's, and Brownings. The Trailside beats them all: great ergos, very simple to clean, very reliable, easy-to-operate levers/safety, lightweight, and a perfect match trigger pull.
I got my 4.5" Trailside for $319 NIB otd. I'm getting the Competition 6" Trailside next with the competition grip and adjustable sights because I liked the 4.5" standard/basic so much.
Most of the other .22's are either really expensive, or are heavy, or use a lot of plastic parts (even the guide rod), or are nearly impossible to field-strip and clean.
I would NOT recommend the NEOS...in addition to the extreme grip angle, the mag release is EXACTLY where your right hand trigger finger should be when off the trigger and out of the trigger guard, causing me to drop the mags all the time...dumb dumb dumb design imo, regardless of Beretta's "progressive" attempt to try to innovate the industry by relocating the mag release to a place where an experienced shooter could quickly drop the mag without shifting grip and using right thumb or left-hand.
I use Remington gold-nose and even though there's a dud every once in a while, it's just as accurate as ely and much more reliable than CCI stuff, and about 1/4 of the price.
At the range, instead of boring old paper targets all the time, on the 2nd hanger (first hanger has paper target) I hang a tennis ball by a string about 16 inches below the hanger...about the same heigh as the bullseye on the paper target next to it...much more challenging and instantly rewarding...much more satisfying to see that tennis ball swing rather than guessing if you hit paper at 7-10 yds, let alone at 25yds unless you have a spotting scope or keep returning the target back to the front. And a lot of fun to try to hit that tennis ball while gently swinging from the last hit. With the accuracy and ergos of the Trailside, my oldest daughter hits a still tennis ball 8-9 shots out of 10, and my youngest hits 4-5 out of 10. My youngest likes to challenge the adults at the range for a plate of cookies and a glass of milk.
Hope you get the Trailside. It's the perfect .22. Besides, how could you go wrong with a Hammerli and Sig collaboration?
Good luck!
Tell me more about your Smith 22 A /S I was going to get one for a cost effective plinker. But, yep that word BUT, I picked up a Ruger MKII 10" excomp gun with Bomar sites frt and rear and Volquartsen grips, awesome trigger job. wasn't what i went to the shop for . It was what i ended up with buying. At $260.00 out the door I couldn't walk. Now i do still want a low cost plinker ,and the Smith even with out the bull bbl (which i thought I'd want) had a decent feel.grips will have to be upgraded. What do you think of yours? I did a post on Rimfire ctrl. and go both ends of the bbl. some say the trigger is bad other say they are accurate as the MKII . The only problem i have heard of the the plastic buffer,and Smith sends ay three at a clip if you call. So I'm told. I'm all ears. I'm picking up the Ruger tonite,got Snowed in last nite. The 22A /S in next on my list ,,maybe. --Jim-- 
