My .44 loads carry my own cast bullets, and have done so for decades. While I've used a bunch of H110 over that period, I generally get better results with 2400.
These are not the wimpish loads often recommended by present-day "experts" for such bullets. The non-gaschecked 250-grain RCBS .44-250KT leaves my 7.5" Super blackhawk at almost 1500 fps, and the 4" S&W .44s give me 1300-plus with the same load, and no, there's no "leading".
2400 is a bit more flexible than H110/296, in that it can tolerate having the charge reduced to a rather considerable degree, which H110 doesn't like at all. Also, it's easier to ignite with various primer types. I usually have a bit of H110 around my shop, but 2400 gets the nod for all my magnum-level revolver loads, including .357 and .41 as well as .44s. All of which makes me a fossil to some, but....my guns and loads WORK, and they work very well, thanks.
Incidentally, another superb powder for reduced loads is Herco, which is an almost-unknown powder to today's handloaders. I like it better than Unique in that role.