Bore diameters vary a little,land height can vary, freebore length, freebore diameter, leade angle all have tolerance. Number of rounds through the gun can effectively change freebore due to throat erosion, which affects bullet jump, pressure,and velocity. Different bullets of the same weight have different ogive contact points and contact angles, also different jacket and core hardness which affects engraving pressure. Powder bulk density varies 3 to 5%, affecting case fill and pressure. Guns have differences in chamber dimensions which change combustion chamber volume and thus pressure / velocity. Differences in finish quality of the bore...the list goes on. Since no one has yet figured out how to accurately predict the net combined effect of all these variables, we are left with no better a system than to experiment.