OIFumbled,
You can look at the costs in several ways, but the point is that by reloading XX caliber, you will recoup "savings" of $x amount. Over time, you will get your ROI.
Yes, you can save a lot more by casting, but I would recommend that you step into the hobby a little at a time.
Get a good understanding of reloading, both for rifle and pistol, since you opened the discussion with rifle powder suitability, and now you are mentioning 45 ACP.
The biggest key in quickly reaching your ROI is volume (loading and shooting) -- that's it! Or, not spending as much up front.
I'm going to give you 2 examples on ROI using real world info:
One of my buddies - Quags on this forum, got started not too long ago. He bought a Lee Turret press, scale, powder measure, dies, tumbler, dies and other tools and equipment. He spent around $410 for the setup. Based on his volume of shooting/loading at the time for 45 ACP, 38 Spcl, 9MM and 223, his ROI was 1.9 months. Since then, he's added more equipment, and more calibers, but needless to say, it's all "paid off".
In my own example, I've acquired my equipment/tools over several years, but over the X years I have spent around $1800 - 2000. 2 Hornady LNL APs, A Rock Chucker, dies for 28 Cartridges/calibers, etc. Based on my volume of shooting -- only for my most common rounds 9MM, 45 ACP, 38 Spcl, 223, 380 ACP. My ROI was in 10 months.
That's based on 400 rds per month of 9MM reloaded cost $5.60 vs store $12 for 50 rds
200 rds per month of 380 ACP reloaded cost $5.25 vs store $16 for 50 rds
100 rds per month of 38 SPCL reloaded cost $5.00 vs store $14 for 50 rds
100 rds per month of 45 ACP 9MM reloaded cost $6.50 vs store $20 for 50 rds
and 200 rds per month of 223 reloaded cost $3.80 vs store $8 for 20 rds (brass cased)
Obviously, if you load 308, 30-06 in volume your savings will be even greater.
I can send you an excel sheet for this if you would like.
The best advice I can give you is save your brass, pick up every piece of brass you see and your brass costs will go WAY down!
One last thing I'll mention regarding costs and powder. Sometimes folks get hung up the price of one powder over another. When you really calculate it, the difference of a few bucks in a pound of powder will be negligible in loading most calibers. Think of it this way - 223 uses around 20-25 grains on average for powder. If a pound costs $20 or $25 how much is that per round? 25grs at $20 is 0.0714 per round. 25grs at $25 .0893.
In reloading the big savings is in reusing the brass.