No.
They used too, before the advent of the frame mounted firing pin though.
The 1917, 1950, 25, and early 625's worked fine with single rounds.
The new ones don't.
S&W is foolishly chambering them with excess headspace now.
Mine, and two my buddy have will not work without clips or .45 Auto-Rim ammo.
The rounds fall into the chambers so deep the firing pin won't reach them.
rc