You'd likely get a slower velocity and definitely a lower pressure. That taking into consideration all the other details being the same - same chamber tolerances, cylinder gap, barrel length, bullet, primer, case, etc...
Using the same charge in a larger volume of space is guaranteed to reduce pressures.
Can't say how much slower they'd be - but could venture a guess that you'd be probably 50-150fps slower based on what I've seen with other powders like 231, Unique, and one or two others I've chrono'd loads through both cases.