I have about 2000 rounds of 230gr 45acp rainier/berry's plated handloads and about 1000 rounds of 400corbon rainier/berry's plated handloads through my G21, the stock factory barrel and an aftermarket 400corbon barrel. I've done 135gr, 165gr and 180gr bullets for the 400corbon, with speeds between 1100fps to about 1700fps.
Mind your crimp and you'll be fine. If you crimp tightly, then make sure you do it cleanly. Bell the mouth before seating, and use a lee factory crimp die as a dedicated seating position.
For 45acp, I don't crimp much at all. 10mm chambers much like 45acp, getting headspace off the cartridge rim. I crimp my 400's pretty tightly since it is a bottleneck cartridge and headspaces off the shoulder.
Do maybe 20 round groups of different crimp techniques - no crimp, mild crimp during bullet seating, heavy crimp during bullet seating, and heavy crimp after bullet seating. See what works best for you.
Also - If you're worried about velocity being a problem, stick to the heavier bullets. A 180gr bullet will still hit like a sledgehammer on-target, but will move a lot slower down your barrel than a 135gr bullet.