What rifle?
blind hog, it is generally accepted that there are three distinct levels of loading for the .45-70 cartridge. Even the lightest, suitable for trapdoor Springfields, is a sure-and-certain deerslayer - - Those loads have plenty of energy, even with "only" the 300 gr. bullets. Higher velocities simply flatten out the trajectory and provide a longer effective range.
The next level is suitable for strong lever action rifles, such as the modern production 1886 Winchester and 1895 Marlin types. These can easily run the 400 to 500 gr bullets out fast enough to make recoil a very vigorous proposition.
Then come the real barn burners, for Mauser bolt action conversions and the heavy single shots, such as Ruger #1 and modern Sharps repros.
Which category rifle do you want to load for?
Best,
Johnny