They will very like function just fine.
But in testing them in a Ruger 10/22, A Browning .22 Auto, a Winchester 06, a Winchester 62A, and and two Colt Woodsmen, I was getting key-holes on target past about 25 yards, and very poor accuracy with every gun I tested them in.
But they functioned perfectly in everything I shot them in. You just couldn't count on hitting anything.
The problem stems from the 1/16 rifling twist rate used in most all .22RF guns.
It is too slow to stabilize the really long bullets!
But the only sure way to know is to try a box of them on paper at 50 yards and see if they key-hole or not.
rc