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I went through the same process of looking at all the available semi-auto .22's just a few months ago - primarily because my youngest son was really getting interested in pistol shooting, and being a big .45ACP fan, I just didn't have anything that was comfortable for him to shoot.
After a lot of research, I settled on a Ruger Mark II 22/45, and I've been really pleased with it. It's an excellent trainer pistol, has features, grip angle and balance similar to a 1911, and has been very reliable. My only gripe with it (and it's pretty minor) is that the trigger pull is a little heavier than I would like, but to be honest all the .22 semi-auto's I tried had the same problem.
After a lot of research, I settled on a Ruger Mark II 22/45, and I've been really pleased with it. It's an excellent trainer pistol, has features, grip angle and balance similar to a 1911, and has been very reliable. My only gripe with it (and it's pretty minor) is that the trigger pull is a little heavier than I would like, but to be honest all the .22 semi-auto's I tried had the same problem.