I'm a handgun hunter, but rather than some 10" revolver, I prefer my 10 or 12" contender barrels, specifically one MOA accurate .30-30 barrel, 12" hunter barrel. It's as packable in a shoulder holster as the longer barreled revolvers and more powerful and a LOT more accurate. Heck, I can take a 200 yard shot on a whitetail or hog with mine, though most I've shot is about 120 yards. Need a good rest for that, though. That's the hard part.
To each his own. Some folks don't think the Contender a proper "handgun", but then, a 10" Freedom Arms revolver isn't exactly a pocket snubby, ya know.
As to single shot vs 6, maybe night hunting hogs you could use the firepower. On deer, one shot is all you'll ever get and the Contender gives a higher quality shot.
As to ol' Wyatt, he got the gun, either built or just given by Ned Buntline, as a gift later in life. I don't know that he actually HAD the gun in Tombstone. He got it after he was "famous". At least, that's the story as I recall it. But, hell, Hollywood, ya know?
Edit, the above post tells the story better. I read that Lake novel about 15 years ago. It painted ol' Wyatt as some sort of savior of mankind. He was not that holy.