Well if you depend on your guns, as I do. I can sometimes have 3 different guns on me. In 4 decades I never go mixed up or confused about how each one works, especially when using them. That is just practice. Most guys carry a backup gun and usually it is different than their main carry gun. When I was a young man I usually carried a revolver, and 2 auto's, one with a safety and one without. My ankle holster gun usually had a safety, but not my main carry, or revolver.
Rotating guns is very common, and should be no problem to anyone who isn't somehow dysfunctional. Most folks do it at some point, especially if I am home vs going to a bad section or area, I am not going to tote a 2lb gun around the house, so a 12 0z pistol may go in a pocket. When leaving I usually strap on a 45, it's a jungle in the cities now.