A 20 MOA base is negative if you're using a flat shooting cartridge, a close (like 100 yard) zero, and don't NEED the added elevation. Running your scope way off centered on elevation tends to reduce your available windage and often gives you a slight reduction in image quality. If you're not shooting at super long distances, it has no benefit.
It's a much bigger negative if you're using a scope with limited elevation adjustment where the 20 MOA base could cause you to run out. Only likely if the scope has 40 MOA or less of elevation, but some do, especially higher magnification scopes with 1" tubes.
Ken Farrell offers bases with 10 and 15 MOA tilts, which is probably about ideal for most shooting at 600 yards or less with all relatively flat shooting (.308 Win / .223 Rem and flatter) cartridges. Why better than 0 MOA? Well just getting a zero at 100 yards will use up about 3-5 MOA vs. perfectly level with the bore, depending on your cartridge ballistics and scope height, so you should get a 100 yard zero less than 10 MOA away from perfectly centered adjustments.