The SAAMI (Sporting Arms and Ammunition Manufacturers Institute) pressure specs for the .45 Colt limit the average maximum pressure to 14,000 C.U.P.. This figure is supposed to closely approximate the pressures developed with full case capacity black powder loads, and therefore theoretically should be "safe" to fire in any quality-made revolver originally chambered for the cartridge and in 'good' condition, modern or antique.
While lots of folks will tell you that the original standard BP .45 Colt load was 40 gr. FFg under a 250-255 gr. lead slug, the S&W No.3 was not designed, or originally chambered, for any cartridge capable of developing pressures at that level. Lengthening the frame to take a cylinder chambered for a longer cartridge does nothing to change that.
While you might not immmediately destroy an Uberti Schofield replica firing lead bullet .45 Colt or .44/40 loads at max. SAAMI pressure levels in it, doing so will be very, very tough on it. It will loosen up enough in short order to require a professional rebuild to return it to servicable condition. Not because it's poorly made, but because it was never designed to resist stresses of that level at all.
Any cartridges loaded to meet or exceed the SAAMI maximum levels for .45 Colt should be considered as unsuitable for use in top-break revolvers -period. Especially those using jacketed bullets, as there is even more stress developed trying to push these down the barrel. IIWY, I'd also take very serious note that the modern 'hunting' and 'defensive' pistols and revolvers that these loads were developed and intended for are virtually all at least an order of magnitude stronger than the SAA.
There are no 1/2 or full 'moon' clips made for .45 Colt. While some of the old Webley revolvers originally made for their .455 service round were imported years ago and converted to accept clipped .45 ACP or .45 AR ammo to increase their salability on the surplus market, the Webley's latch design is much stronger than the No.3 - Schofield or otherwise. Not only is the average pressure limit for the .45 ACP much too high (21,000 C.U.P.) for other top break designs to handle, the conversion would be extremely costly - even in the unlikely event that you could find a reputable 'smith willing to do the work.
IMO, if you want or need an 'all-purpose' .45 Colt revolver you'd be happier and better served buying a Ruger Blackhawk or Vacquero, a high-quality SAA or Remington 1875 replica, a S&W M 25/625 or the like.