Just a few observations from my years of concealed carry, and having to show a gun twice to save myself from unprovoked assaults.
1. You are unlikely to need a gun with large cartridge capacity...two shots is fine. You are highly unlikely to find yourself in a protracted gun battle. Range is most likely to be under 5 feet. There is no need for the cartridge to be high-powered...just use an efficient HP or SP bullet.
2. For concealed carry, the objective is to minimize the chance of others seeing your gun unless you need to. You don't want to be accosted by police responding to a "man with gun!" complaint. Therefore, you want something small, flat, and light that you can carry in a way you can access it immediately in time of need.
3. Given those constraints, the more powerful the cartridge, the rougher it is going to be on you to fire it.
4. I use three guns, choice depending on clothing I'll be wearing and the social occasion. The largest is a Bulgarian Makarov in 9-mm Mak, Gold Dot ammo, worn at the waist with my shirt out to cover. My evening and night gun is a S&W Model 642 5-shot .38-Spl Airweight with Crimson Trace lazergrip, carried in a pocket in a soft, form concealing, pocket-gripping DeSantis rubberized foam holster. My high concealment gun is an over/under derringer in .357 Mag, which I use .38-Spl in, carried in a soft, suede holster that I can clip inside my waist or in a pocket. And that's really rough on me to fire! .357-Mag would be insane.
Bottom line: Any gun large enough to fire your .45 LC is likely to be both large enough to get you into trouble, and heavy enough to eventually be uncomfortable and inconvenient. It'll sag your pants!
My Ruger Blackhawks in .45 LC and .357 Mag are two of my favorite range guns. But I'd never try to use them for CC, and they get pretty heavy on limited OC.