Hello Airpower.
Nothing beats stock minty factory grips when it comes to the collectability of an original Colt.
As for shooting that Python of yours. It looks to be a set of Badger boot cut grips you have on her currently. Badger makes some wonderful grips and I myself have a few different sets. I find that the boot style like you are showing only allows a 2 finger grip. The pinky on your shooting hands sits only on the bottom. Badger makes a full sized grip that allows the shooter to get a FULL grip. The trouble with the boot grips is that if you shoot some hot loaded 357's through your Python, you may not feel totally in control. If your Python is a shooter for you, and you like the aftermarket look, you may want to purchase a set of full size badger or hogues to wrap that gun with.
Truth is, some of the aftermarket grips like the laminated badger & exotic wood hogues are getting very pricey as of late. You will end up paying in the $60-80 range for a NEW set.
If she's not a shooter, put an original Colt set back on her.
Hope that helps.
Jeff (GUNKWAZY)