I'll pass on the big bruisers. I've fired .44 mag, hot .45 colt and that level of round and they're not bad depending on the firearm. They friggin' HURT in a contender, but in a Ruger, not bad, the recoil just sorta rolls the gun up in the hand. My bud has a 7.5" superblackhawk and it's a pussycat. My .45 colt blackhawk ain't bad. When I got my .30-30 barrel for the contender, I got the 12" compensated hunter barrel, kicks like a .38 in a K frame!
Asside from recoil, I can't justify a "handgun" that weighs as much as a rifle. They're bigger and heaver than a contender! Those short barreled ones are a joke, too, I mean, what's the point? You trying to start a forest fire?
I think I could probably handle the .454 Casull in a single action (love the way they handle recoil) though I've yet to shoot one, but that'd probably be my personal limit. I can't justify owning anything bigger anyway. If I need a gun with that much power, I'll use my 7mm remington magnum and add some range and accuracy to the equation. My .45 colt, heck, my .357 magnum blackhawk will do about anything I need doin' with a revolver. I don't live in Alaska or Africa and will never get a chance to go there.
Next time I read a thread that says the sub-compact 9s have too much recoil, I'll direct 'em to this thread.
Some people make that arguement against the Kel Tec and Kahr baby 9s. I guess they'd never consider a .357 magnum, let alone a .44.