The .22-250 has been the preferred rifle of large ranches in California for the last 40 years as for what I saw. When they deliberately went after bigger dear, bear or Elk they took something bigger but the .22-250 rode with them allways, along with a .22 . I found a tough 55 grain bullet , not a Varmint thin jacket type, will kill Blacktail local deer very nicely to 400 yards and works nicely on the neck shot especially. In the late 70s thru the 80s I used a .224 Weatherby Varmint Master German made with the factory 55 grain bullet . This is about 200 FPS slower than the .22-250 but was a super little Blacktail rifle and death on coyotes and mountain lions back when they were hunted, I sold it 10 years ago. Anyway I have a Browning B78 ,22-250 I bought new in 1979 with a 12 power Leupold that had a couple thousand rounds thru it and is still sub MOA accurate. Now wanting to wear out the browning and wanting to be able to shoot heavier 60 grain Nosler Partitions and even the longer new new bullets of the middle 90s I had a 1-9" .22-250 AI barrel put on a pre 64 Winchester Model 70 Varmint with a shot out .220 Swift barrel I bought cheaply 25 years ago . It has a big old 6-24 Baush&Lomb American made external adjustment scope and it is death on stuff as far as I can shoot it if it weighs less than 200 pounds .It loves the 75 grain A max bullets and gets 3500 fps with H414 easily. I Bought last year a Weatherby Vanguard .22-250 and I shoot the good old Sierra 55 Gameking at 3700 fps and use it as an all around truck rifle. I also have .22-250 loads of the 60 Grain Nosler Partition that work in the weatherby well , but never worked in the Browning B78 . Of course they work very well in the Winchester. They are real deer killers., as are the lighter Barnes 53 grain copper bullets in the slow twist guns and the heavier weights in faster twist guns; now mandated in Calif. !!!