My Rem. M700 shoot bug-holes with a quality 50-55gr bullet (Sierra) and 39.0gr of H380. 40.0 is over max for my rifle as it craters primers.
It also shoots essentially as well with 35.5gr of IMR4064, same charge of Reloader15, and 33.5gr of Benchmark. Due to lower charge weight, I'd opt for the latter if shooting P'dogs in volumn.
There is over 3 dozen powders that can/do give superlative performance in the .22-250, so pick your "poison".
FWIW; I'd start with Benchmark, Reloader10, IMR8208, and some of the new CFE-223 or PowerPro 2000LR. Even Hodgdon's "Superfomance" powder is listed for the .22-250 at top velocities. An old time favorite for accuracy when everything else fails is IMR4350 or IMR3031.
Where I'm at, seldom do I hunt when temps are below 20degF. so H380 is hard to beat.
FWIW: the BULLET makes much more difference with my rifle than the powder charge. I can switch to a Hornady 55gr Spt w/cannulure and groups go to over 2"(Ditto Rem, Win, and PrivPartisan). So, anything with a cannulure is "suspect".
If it ain't a Midway "Dog-town", Sierra (any w/o cannulure 40-63gr), Nosler (except Partition), or Midsouth Varmint "Nightmare" or "Extream", I don't bother (Haven't tried the Speer's.......).