For a temporary fix that works well.
Wax the threads of the screw lightly with parifin or Johnsons Paste Way and pit a drop of JB Weld in the hole, then thread the screw back in and let the epoxy set up.
When it sets up, the screw will still be removable, but not as durable as having it drilled out and rethreaded properly.
Wax any parts that you do not want the Epoxy or JB Weld to stick to, like your barrrel, or sight base.