I once emptied an entire 16-round magazine from a 10/22 into a skunk. I shot it in the head, the torso, the head again. I saw the eyeball pop out through my scope so I know I shot it through the eye. And the darned thing slowly crawled away. I reloaded the magazine and started shooting it some more, until it finally crawled into some brush. It being a skunk and all, I didn't want to get too close. I felt bad about not killing it, but I gave it my best shot.
I think a skunk might have tougher skin than a human, and as someone noted, I too would hate to get shot with a .22LR. As someone once noted about the infamous Los Angeles shootout, the cops would have been better off making a few headshots from a 10/22 than emptying magazine after magazine of 9mm into the BG's body armor. Still, when it comes to personal defense, more power is always better. I keep a Ruger PC9 and a Mossberg 12-gauge within reach of my bed. I plan to add a .357 Magnum shortly. I've seen a deer drop from one .357 round so it aught to do the trick on a bad guy.
BTW--I'd prefer a BG on cocaine to a BG on crystal meth. Cocaine makes them wired--meth makes them wired and crazy. The way this terrible stuff is tearing through rural America, I'm afraid we are about to see a huge increase in all kinds of crime.