What powder measure are you using? Large or small metering chamber? Powder baffle in powder reservoir? Consistent operating speed and force on powder measure handle? Suggest: small metering chamber, powder baffle, consistent operating motion. Use of large metering chamber, no powder baffle, and inconsistent operating motion can cause substantial weight variances.
For small/med pistol charges (1-20 gr) I use Redding Competition M10X-Pistol powder measure. Never had trouble metering #2400 or any other pistol powder. Other good magnum powders are W296/H110. This is reported to be the same powder marketed by different companies under different names. I use W296 and it works great in my .44 Mag revolvers.
Good shooting and be safe.
LB