I have several 22's at present.
The Sig Trailside is very accurate for a production gun and has a good trigger, although mine is a bit finicky about ammo. I have a red dot on this one and do quite a bit of plinking with it. I probably would not buy another one just because mine is so darn picky about ammo. Not sure on the current price but I think they are around $400 now.
Beretta model 76, excellent all round pistol but no way to mount optics if you need them, the newer model has optics mounting capability. It's more accurate than the Sig by a small bit and has an excellent trigger. I like this pistol a lot and would buy one again, or one of the newer versions with optics mount if I needed another 22. The current version goes for about $599-650 and it's actually worth that, they are hard to find as Beretta apparantly only makes a small number of them.
Early last year I managed to get an excellent used High Standard Military HD model with the long barrel and it's a superb pistol (for $325 this was the steal of a lifetime for me). Very accurate and the best trigger of the bunch. It's a little on the big side for kids to shoot, and even for me the Beretta seems more comfortable in the hand. I'd buy another one of these even though I don't need another 22. A more realistic price for these today is in the $450-550 range in excellent, some people will try to get more but that's what they actually sell for.
Ruger Mk1, 4 1/2" barrel, good plinker but certainly not in the same league as the Beretta, Sig or HS for accuracy or trigger. Not sure what to say about Rugers without getting flamed, I guess it's the best inexpensive 22, if you're spending around $200-225 you probably can't do any better.
I've also shot most of the current offerings and the Browning Buckmark seems generally ok, hated the trigger on the Walther, didn't care much for the trigger on the Beretta Neos. The inexpensive S&W models are ok plinkers also but nothing special.
If you are looking at high end pistols, of course the S&W Model 41 should be considered. If you want something really special then a Pardini is highly recommended. I sold mine to a friend several years ago in a moment of weakness and have regretted it ever since. Sure, it costs over a grand, but a better shooting rimfire pistol was never made in my opinion.