The only reason I would ever keep a gun I intended to use for HD in a safe would be to prevent children in the house (assuming I had some) from accessing the firearm. In that case, I would remove it from the safe when I went to sleep and put it back in the AM. Home invasions are usually executed using the military principles of a raid- speed, surprise, and violence of action. IMO, going from a dead sleep and transitioning to the combat mode is challenging enough when your gun is accessible. Doing fine motor skills required to open any safe and put the firearm into action would be even more difficult. Also keep in mind other things you may want to be doing in your action plan- and add opening the safe. Try this drill- have your S-O wake you up one night from a dead sleep and perform a similar function like unlocking your Iphone, which you have placed under the bed. Keep an empty shotgun next to it, and put it into action (minus live ammo). However long it takes is wasted time that you won't have time to waste when its for real.