After years of buying 22 handguns, it is better to save for the higher quality gun and keep it.
That said, I have heard the Heritage Rough Rider is an okay revolver for the money. Important qualification... the money. It is cheaply made and will not least if you shoot it a lot. If you are like most, you will shoot it a lot at first and then slowly dial down the shooting or you'll add another 22 handgun and the shooting is spread out between the two or three.
If it is a matter of getting the Rough Rider or nothing, choose the Rough Rider. Shoot, enjoy, and learn. It is time well spent.
If you have a choice, let's say two single actions.... Heritage Rough Rider and Ruger Single Six, you will almost always choose the more expensive one to shoot. That should tell you something.
The old Colt SA's are good revolvers too and most came with two cylinders. I personally choose Colt over Ruger. But that is me.
If you are leaning toward a double action revolver and that is my preferred 22 revolver choice, I'd buy the Smith Model 17 or the current 4" Model 617. I always preferred Colts, but they are pricey now. But, a 4" Colt Diamondback 22 for $800 in as new condition would be a very good choice. They are my favorite 22 revolver. Easy to pack. The have a nice size, have top notch quality, and are quick pointing.
You generally get what you pay for when it comes to revolvers. Semi-auto 22 pistols are cheaper. Choose Buckmark or Ruger Mark III there. Very good guns.
Some will suggest you find a used H&R 999 Sportsman model (probably under $300 in good condition). They are fairly good guns for the money and probably a bit better than the Rough Rider and they are double action. H&R made a lot of different models. The 999 was their top of the line at the time. That was my first 22 revolver. It was a learning experience. I bought a Colt Diamondback a few years later and never shot the H&R again. Sold it off after letting it lay around for about 10 years.