Think Colt 1911 for size (FYI, many .45 holsters will fit the CZ). Like the Colt, the CZ-52 is a single-action auto. Unfortunately, it doesn't have a grip safety which would make me a little nervous carrying it "cocked-and-locked". Accuracy and reliability are very good. However, if you do get one, plan on replacing the firing pin with a machined aftermarket piece. The stock cast ones will break easily.
As to the cartridge, most new production ammo is actually downloaded from the original Czech military issue. This is due to the fact that the Soviet Tokarev's share the same cartridge but are not as strong (the Czech's load them MUCH hotter). The round will often overpenetrate but not as much as most would have you believe. Most of this reputation comes from the hot milsurp ammo which will penetrate almost anything you'd want (or not) including vests. Several sellers on Gunbroker.com are now selling new ammo with the 85 gr. Hornady HP which will reduce the problem with penetration.... BUT they are HOT, HOT, HOT!!! The box I recieved from Ron Reed states that they are ONLY for the CZ-52 NOT the Tokarev. He also recommends upgrading to a stouter recoil spring. They are noticibly beefier loadings (more recoil, flash, noise). You could also roll your own as Hornady makes SP, HP and FMJ for it. It IS a .30, not necked down from one.
Do what you're comfortable with, but if I were doing it (I own 2 CZ-52's) I'd go with something else for carry and throw a -52 in the drawer or keep it for range work. Just my .02
Take Care,
Mike