I like squirrels. I tend to feed them, not shoot them. If you're planning on eating them, or if they are causing damage to your property then by all means, but I don't really see the justification in just gunning down living creatures for fun. If I was hungry enough .. I'd use a .22lr. As Mr510 said though, NEVER shooting upwards into the trees. I voted for bolt .22 , simply because it's probably something I'd use my Savage for since it wears the best optics of my .22s, but any .22 would do really.