Long ago I learned two things: never sell a gun or real estate.
About three years ago I realized that I had accumulated every gun I ever wanted (forget "needed") and yet, there are still some few "wunna those'd be cool to have" on my list. If I see one, I'll buy it if the mood strikes me. I don't intend the previous two sentences to be snarky, but rather a statement of what you can do over 50 years or more of active accumulating.
As for the original post, the question seems to be one from someone starting out and wondering which two shooters he should choose first.
My answer is: IMO EVERY man needs a basic battery of 5 guns. Those should be (in no particular order)
a centerfire rifle
a centerfire handgun
a rimfire rifle
a rimfire handgun
a 12 (or 20) gauge shotgun
Action types and calibers are personal choices and should depend upon a host of variables, beginning with "WHAT do you intend to actually shoot with the gun?" Robins? Rabbits? Robbers? Rhinoceros? or a herd of scimitar waving al-qaida storming down Elm Avenue?
Frankly, if I could only have two shooters, I do believe my choices would be a Mossberg 500 combo 12 ga pump with the short riot barrel and long hunting barrel with the Ventilated Rib. Big Five regularly sell this package here in California for $279.
My other choice would be (east of the Mississippi River) a S&W L Frame 357 magnum or here in the west perhaps a S&W N Frame 629 in 44 Magnum (critters are indeed bigger out here in the west). Both of these shooters should wear 4" barrels, IMO.
A good wheel gun is critical to have in your battery IMO and is more versatile than any other handgun - PERIOD!!!
Having said that, I'll add that during most of my swamp and woods, and river running in the south before I was 35, I was carrying my old reliable Ruger Blackhawk 357. I killed boar, bobcat, even a bear with it. The bear was dropped in its tracks with a single round of Lee Jurras' Super Vel (130 grain bullet at Warp Factor purty-dang-close-to-speed-of-light). I was once treed by a pack of feral dogs and fought them off with it as well. So, I can attest to the adaptability of the venerable SA revolver.
For years, I packed a S&W 3" 629 Trail Boss in the boonies. Following a close scrape in the desert about 7 years ago, I started carrying a 45 ACP. The critters that'll get'cha out there are not 4 legged. My carry piece was my full sized Kimber until I found a Glock 30 SF. Now I carry it.
And there's a 12 ga Coach Gun always close at hand. Yes, I still have my Mossberg 500, but the Coach Gun is a mite handier across the forks of my ATV.
So there ya go - one old man's opinion.