My goodness fellas' deer, hogs, and black bears aren't M1A tanks that require a photon torpedo from your handheld mega blasters. The .454 Cassull, .460 S&W, .475 Linaebaugh, and the .500 S&W are all great cartridges as are the guns that chamber them. Those cartridges are more specialty cartridges than anything else. It dang near requires one to take out a second mortgage on your home just to shoot the dang things too, they're not cheap.
I just got done reading another excellent article written by Brian Pearce in the new handloader magazine. In it he talks about a bear hunt that he an his son went on. His son used one of the Lipsey's mid framed Flat Top revolvers chambered in .45 Colt. This frame size is limited to 23,000 PSI pressures, so the same pressure that a .45 ACP+P load would produce. He worked up a load for the RCBS 285gr Keith bullet that would produce approximately 1050fps.
His son took a treed black bear at 40 yards with that load. All rounds passed completely through, leaving behind severe wounds and internal damage in the process.
To the OP, I'd look for a good .41 mag, .44 mag, or .45 Colt and some good ammo loaded with a Keith bullet. Be prepared as none of them are exactly cheap to buy ammo for, reloading may soon be in your future.