Welcome timmerk,
Boy, ask a simple question...
you'd think you'd get a simple answer, no?
As others have stated there are Several Categories and calibers worthy of consideration:
Plinking... some form of .22lr (cheap to shoot, easy to learn, minimal recoil, you'll practice a lot as a result) Ruger or Browning make good semi-autos in this category (as do others). Revolvers by S&W, Ruger are good.
Centerfire... both semi-automatics and revolvers... several calibers...
target shooting...(and self defense)... can't go wrong with a S&W Model 10 (Revolver) in .38 special with a 4" barrel, it can also help protect house and hearth and Cops carried them for years. Then there's the .357 magnum, developed back in the 30's. Its a .38 with a longer case, holds more powder and as such makes a bigger bang and these bullets travel a lot faster. Almost always a revolver (but for the Coonan and maybe one other no longer mfg type of Semi-auto) Cops carried these and loved them (some still do). Not exactly cheap to shoot, but they will take the .38 special round so you can shoot them on the cheap. Colt, S&W and Ruger make good ones. (as do others)
...also some form of 9mm (usually a semi-auto) as ammo is relatively inexpensive. Too many good makers here to list but middle of the road variety types would include Glock, Beretta, Ruger, S&W and Sig. Some cost more than others, some are ugly, some are clunky, some cost less, some feel better in your hand (tho not necessarily mine), some have fixed sights, some adjustable sights... Cops switched from Revolvers to hi-capacity wonder-nines in the 80's but the Clinton era hi-cap magazine ban kinda put the skids on that (tho Law Enforcement and Military can still buy new hi-cap mags). Uncle Sam uses the Beretta 92 (called an M9 in the military). The Luger was probably the most famous 9mm semi-auto.
The .45 has been around for awhile now and its a good one. If I was going to war, I'd want one (I have several). Costs a little more in way of ammo than the 9mm. Makes a bigger hole. Colt, Sig, H&K, Glock, S&W and others make them as do others. The grandaddy 1911A1 used to be only (mainly) mfg by Colt, but there are so many mfg of 1911's now you could write a book on them and there'd be another maker by the time your book got published. Its hard to go wrong with a 1911 in .45 acp
The .40 S&W (where to begin?) is a 10mm round sized to fit in a 9mm format firearm. Bigger than the 9mm, smaller than the .45 (about an 11 1/2mm) Beaucoup makers. Ammo is not really cheap. Lotsa Cops going to that round.
Hunting? Cowboy? Collecting? .44 magnum, .44 special, .45 Colt and others... mostly wheelguns.
CCW? Small is good. Kahr, little Glocks, S&W and Colts, Sigs, Berettas all make good smaller sized (whats the derogatory buzzword that HCI used "Pocket Rockets"?)
Well, you can see the dilemna when you ask "What is the best maker/gun?"
The safe and best answer is, get one of each eventually. Then you tell me.
Spend a weekend looking back through the threads here and on The Firing Line, spend a week or three shooting and asking obnoxious questions at the range and at gun stores. Check out prices at
www.gunsamerica.com to see what costs what, new or used.
Let us know whatcha get whenya get it.
And did I say Welcome? I like simple questions timmerk, keep it up. Just don't ask which is better, the 9mm or the .45?
Adios