IIRC, there is a magazine incompatibility, if one owns one of each? I think I may have seen this on Garand Thumb’s you-tube. Perhaps the G19x cannot accept a Gen5 mag, due to that projection, at the front of the mag well? I only have the G19x, and not yet a G45, or a Gen5 mag, so have yet to experience an issue.
Gen 5 mags won't fit on the 19X, the baseplate toe is too long for the lip of the 19X frame. Replace the baseplate with Gen 3 or 4 and it'll run fine. Magpul mags may or may not drop free, they do on mine but others have said they don't on theirs.
The 45 has a flared magwell, the 19X does not, the 19X has a front strap lip and the lanyard (I like the lip, lanyard is removable).
Finish is different, Gen 5 is slicker and shinier, 19X is tacky even when wet. I feel Gen 5s need the front serrations when wet/sweaty and the 19X does not.
Internally the only thing I'm aware of is the newer Gen 5s have a little cutout on he breech face that's supposed to help with ejection and the 19X does not. Can't say I see much difference in ejection myself (though my Gen 5 is a 19, but I can't imagine the 45s slightly longer grip would make a difference).
My 19X and 19.5 can interchange slides with no issue, I've done that plenty.
I looked at a 45 some at the shop when I was debating a 19 MOS or 45 MOS (because I like my 19X so much) and can't say they feel much different in the hand, though I do slightly like the lip on the front strap of the 19X a bit more as a nice place to rest my offhand pinky, folks with smaller hands probably wouldn't agree.
I wish all Gen 5s used the 19X finish. Mine has held up really well and the tacky finish would have alleviated the need for the ugly (IMO) front serrations*.
*Yes, I understand folks equate Glock with ugly, but I found appeal in the clean utilitarian lines of the Block, lines ruined by the necessary and useful serrations with the Gen 5 finish.