I have ran the spectrum from 22 short up to 44 mag in revolvers, 22 lr to 10mm in semiauto, with .45acp in the mix. In single shot handgun I have ran from 22lr to 44 mag, with the 7-30 waters being a notable under-rated cartridge. I will aquire more TC barrels in "energetic" chamberings. I know I want .223, 35 rem, and 30 herret.
To the second part of your question...no the modern big bores are not suitable for most things. They are expensive to buy, expensive to feed, and uncomfortable to carry. These downsides don't come close to the huge recoil that prevents much needed practice with these pieces of handheld artillery. They are purpose built tools. They keep people at the top of the food chain when in other situations they may be on the dinner menu for a bear, lion, tiger, etc.