Confederate, there is no magic bullet. The 125, while a great round, is not the hammer of Thor. I used to have 125's stoked in my .357 until I started working with inmates.
I switched to the 158gr because I want the greater penetration (than the 125). I want to know that I have a round that can hit vital structures even if the bullet has to enter the arm through leather, go through 4" of muscle, humerus, exit the skin, leather, re-enter leather, chest wall, rib, then lung...heart...or spinal cord. I use 158 for deer, 185gr LBT for boar. Some of these SOB's are much bigger than a deer, and almost as smart. I'll stick to a round that has a good chance of penetrating to the heart, even If I have to shoot through his a$$ to get it there.