Let me echo some of the others: The Remington Golden Saber 125 gr JHP in .357 Magnum is a nice "80%" round. In a 6" K-frame like yours it will be easy to control. You should get good accuracy, and decent numbers, too: maybe 1300 fps. Perfectly sound defense load.
My only beef with the 125 GS is that it's flashy. Wish Remington would start loading it with flash-suppressant powder like many other manufacturers do with their quality hollowpoint loads.
Still, it's a fine round.