Not all pockets are created equal, nor are all fabrics or pants equally supportive, so I have Kramer pocket holsters for the Ruger SP101, S&W J-snub, and Seecamp LWS. I also have left and right Del Fatti pocket holsters to fit the Seecamp.
I tried the Glock G27 in large pockets when I was carrying G22 duty pistols ten to twelve years ago, with a quite well-made but now-forgotten brand of kydex pocket rig. I rather quickly returned to using spurless revolvers, as the bulging rear of the Glock slide, necessary to contain the striker mechanism, complicated the smoothness of the draw, and if there is anytime a draw needs to be smooth and unimpeded, it is while drawing from a pocket during a real-life emergency.
For me, except for inside the home, a pocket gun is almost always a secondary or tertiary weapon; "primary" has long been at 0300, at belt level. If a close-range fight starts without warning, drawing from a pocket can be problematic if one is bent at the hips or waist.