What barrel twist are you working with? I have an 8 twist, so I usually use the heavier bullets.
For hunting deer and similar I like the 140 Berger hunting from my 260 at about 2800 FPS. Heart and lung shots are killer. I would avoid shoulder shots; tuck them in right behind and you will be golden. I have just transitioned over to this bullet last year for hunting. A couple deer so far from 80 to 515 yards. All shots were into the lungs and did just what they were supposed to. Much more internal disruption than the AMAX I was using before.
Prior to the Berger i used the 140 AMAX at 2750 FPS. Very good price (the new ELD should be similar on game, but I cannot personally confirm yet) and did well on deer. Probably 15 kills with the amax from 20 to 550 yards. Some head shots on the close ones and all others were lung/heart shots. Past 200 yards generally gave a quarter sized wound track and a slightly larger exit. Bullet was effective and accurate, so no complaints. Kinda nice to use the same bullet ALL the time.
For targets I would have to give hornady ELD bullets the nod. They are affordable and seem to shoot well like the AMAX. The sierra 142 seems to do well too, but I have not shot nearly as many. The Berger target bullets seem to be VERY consistent, though I have not followed that rabbit down the hole simply due to cost.