I usually carry one of my pistols, used it the first time this season on an 8-point. I carry my .45 Witness with me, for 3 reasons really.
1. Personal defense against any type of animals (skunks in particular) and against the pissed off out of state hunter that might wonder on the land I hunt on. Out of state hunters in my area have been known to be awful shots, and have been known to also jump fences and shoot at everything that moves.
2. I am often put in situations where a full power scope is obsolete. Having a pistol, .45 or .357 at 10-15 yards is deadly. Still haven't shot one though, but I will one day.
3. Making a mortal wound quicker. I can't stand to see animals in pain, so I have always took one for that reason. I've used it only once, having make a lucky but bad neck shot on an 8-point. I immediately ran up and put a .230gr bullet through its vitals, making the animal expire within seconds.