H4350 and H414/WW760 have done well by me and my custom .243 Mauser varminter. Sierra and Hornady 75 grain HP's and 55 grain Nosler BT's will do sub 1/4" 3 shot groups at 100 yards and measured velocities for the 75's are 3450 fps, and the 55's cruise along at 4015 fps. To maintain good accuracy, I have found magnum primers a must with the two ball propellants mentioned.
As expected, these bullets have explosive terminal performance on Rockchucks and Groundhogs, and Crows disappear in a "black puff of smoke" when introduced to near mach four 55 grainers.