It's interesting you say that. I load for 4 primary handgun cartridges... 9mm, 45ACP, .41MAG, 45 Colt. Of those, the .41 and .45 get Unique 99% of the time (for pistols,) and something like IMR4227 the rest of the time (for rifle loads.) That leaves 9mm and .45ACP...
About 2 years ago I set off to find a replacement powder for both cartridges... thinking Unique was a little outdated, and in my 4" 1911's... not very efficient. Long story short, after working my way through about 5 different powders, I settled on W244 as the powder that worked best for me in both 9mm and .45ACP (with 200grn bullets.) What was interesting was the amount of tweaking I had to do to get them to settle down and show not only reasonable accuracy, but good SD numbers and a clean burn. It was actually quite frustrating. I never have that problem with Unique... dump the powder in, mash the bullet somewhere near the recommended OAL... and you have an excellent cartridge without all the fuss. So... I've come full circle... Unique still has it's place on my bench, now until the end of Time, and I've decided all the newer powders are not All That and a bag of chips.