I love H110/W296 for my heavy 460 S&W and 44 mag pistol loads. Of course, I'm going for the flash and bang.
When I was working up loads for my Desert Eagle 44, I tried several powders. When I got to the range to test them, I started out with my N-110 loads first, then the H-110 loads. Shooting them back to back, the H-110 loads were much louder and had more flash. Much more, even though they were essentially the same velocities. Both shot very well. If you don't want the big flash and bang, then use N-110 or 2400.
I've tried several powders in 357mag, and H-110 performed well for me with 158gn jacketed bullets. For the lighter 125gn bullets, I actually prefer BE86, and HS6 worked well, too.
But, for my 357 and 44 mag rifles, I much prefer 300-MP, where I get more velocity and accuracy.
Here is my DE44 with H110 loads: