As long as it is a bullet designed for deer or larger it will work fine for any angle. If you put in perspective a 243 100 grain has about the same sectional density as a 150 grain 30 cal. bullet. That means all else being equal, construction , muzzle velocity, range, and point of impact, that penetration will be about the same. The wife has used a 250 Savage for more than 30 years. I have used one for 7 or 8. Dad used a 257 Roberts for the last 15 years he hunted. All were with 100 grain bullets between 2850 and 3000 fps. Not sure how many deer these accounted for. More than 40 for sure. Broadsides were pass throughs. Quartering shots were about 50% pass throughs and depended on if a shoulder was hit going in or out depending on angle. Straight on shots ended up back in the guts somewhere. Plenty of penetration.