45 ACP Has well established stats. 38 Supra Does not. Since it slightly out performs 9mm +p+ I would add a couple of performance slots up to about 93% putting up with 357SIG. I would consider the 125 gr HP at 1250 to 1300 FPS range to better duplicate the magic of 357MAG golden performance of the 125 gr HP round . In the limited reports I have read because of its penetration it may zip through the human body without delivering the shock value of Big slow tissue crushing effect of 45 ACP creating the issue that 158GR bullets had with 357mag. Yes it will kill you, but minutes later as opposed to right now.
Having said all that. Good shot placement in the magic triangle with good HPs should rapidly end the confrontation with either 45ACP or the 38 SUPRA. The magic of 45 ACP is it breaks 90% in one stop shots with a variety of bullet weights. 357MAG, 38 SUPRA, 357SIG, AND 9MM do not. 40 S&W breaks 90% and many rounds with high 80s.
Edge to 45 ACP, 40S/W, 10MM, 357 SIG, then 38 SUPRA.
Would I carry one. No, I subscribe to big slow! with the exception of 357mag which I use as my back-up.
Total ONE SHOT% EXPANSION--PENETRATION
Remington 185 gr GS 83 80 96% 0.69" 12.4"
Federal 230 gr HS 173 166 96% 0.76" 13.9"
CCI 230 gr GD 45 42 93% 0.68" 12.2"
Corbon 185 gr JHP 20 18 90% 0.78" 11.1"
Remington 185 gr GS 39 35 90% 0.62" 11.3" 4" barrel or less
Remington 230 gr GS 10 9 90% 0.73" 12.9"
Federal 230 gr HS 28 25 89% 0.68" 12.9" 4" barrel or less
Federal 185 gr HS 78 69 88% 0.67" 12.9"
Federal 185 gr JHP 128 112 88% 0.71" 11.6"
CCI 200 gr JHP 139 122 88% 0.73" 12.4"
Winchester 230 gr BT 96 84 88% 0.75" 13.9"
Winchester 185 gr ST 121 106 88% 0.78" 11.5"
Winchester 185 gr ST 27 23 85% 0.67" 10.2" 4" barrel or less
http://www.handloads.com/misc/stoppingpower.asp?Caliber=18&Weight=All