I went from a Lee Turret to a 650 a few years ago and couldn't be happier. I might be the only 650 user who doesn't have a case feeder, but, as they say, ignorance is bliss.
I only load handgun ammo on mine, and only use small primers. I have 2 extra toolheads already set up with dies and dispenser, so switching to one of the other 2 goes very quickly.
I've had very few (and then only minor and easily addressed) issues with my 650. The auto-index feature is very nice. It seems that, at matches, when someone shoots a (rare) squib or (even rarer) double charge, it often comes out they used a press without the auto-index feature.
FWIW, I don't use my 650 to load rifle rounds, not even 5.56/.223 - I use a Co-Ax single stage for that.