I have owned three fullsize PX4s over the years... one in 40 (ONLY 40 cal handgun I have ever liked enough to own) and two in 9mm.
They are very nice guns. However, I find the gun a bit slippery. And, I wish they had slide indentations on the side, like Glocks and other guns do. They shoot very well, but the grip isn't my favorite.
I do prefer the compact PX4 model more than the fullsize - which is what I currently have (a compact - it still has the rotating barrel, unlike the subcompact model). I don't care for the fullsize Hogue Handall - but the Hogue Jr grip on the PX4 compact is just perfect. I have the same Hogue Jr on my HK P2000. They work great on a gun with a slightly shorter grip.
I will say that I still prefer the 92 platform over the PX4, however