During the first half of production the original was inaccurate. They changed barrels eventually but two of the three I used were terrible. It also had coil springs rather than leaf so the pythons perfect trigger was very much absent. The new one has leaf springs and a much better smoother trigger (albeit heavy in da and sa modes alike). None of the three i used had great lockup either and all three were new. The new ones have Excellent lockup. And since the original was not hand fitted with machined parts solid parts (like the Python) and used investment cast parts (like a smith or Ruger) .....to fix the timing wasn't a re fitting issue it was a back to colt for new cast parts issue.
One of the worst things about the new python is that you give up the beautiful "royal blue" finish. The original anaconda was only available in the easier to produce stainless (or camo) so you give up nothing and gain a better trigger, stronger frame, better lockup.....
Use a Python and an old anaconda and the difference is glaring. Ive heard some Anaconda were ok but even before the internet the Anaconda was the colt that most colt guys didn't want. If not for the resemblance to a certain character in a bad tv shows gun, it wouldn't be so valuable. It lacks everything that made the python so loved.