Dan Wesson 715.
Versatility is unmatched when you have different barrels and can swap them in minutes while sitting in your truck or easy chair. You can literally take it from being a silhouette/hunting weapon to a short barreled carry weapon in no time.
I have one of the older Monson models and it's a tackdriver. I know a lot of people say that about guns, but with this one it's very true.
One gun that does a lot of things and uses one of the most versatile calibers in use today. Hard to beat.
I would also suggest something very cool like a USFA replica of the old Colt Single Action, such as the Gunslinger model.
If you're doing target and secondary hunting stuff, then a single action is not a bad choice. They're classy. They're of a uniquely American styling and ethos, being faithful copies of the old Colt products. And, they're made very well.
You can order an extremely nice top-shelf revolver from USFA with whatever options you'd like. If I only had room for one, and I were buying a new one, I'd buy an heirloom quality firearm and maintain it fastidiously while using it regularly.
My suggestions are pricey, but you made no mention of budget. This is the internet, after all. We posters are good at spending the cash of others without regard for much more than desire and some academic reasoning that barely stands on its own.
So, if you have a budget, please say so.