At the risk of not answering the OP's question....I'd say that if you buy any gun that's unpleasant to shoot it's unlikely that your wife (and maybe you) will stay interested in shooting at the hobby level. Further, if you don't spend enough range time with your guns (say, if you don't like the recoil, etc.), you are at a disadvantage if you ever need to use one to defend yourself. I'd also say that if you haven't spent much time around guns you are better off with a revolver or DA only pistol. The advantage of the S&W Model 10s people are talking about is that they are built like tanks, fun to shoot, and with 38SPL +P ammo, will be an effective man stopper if need be. You can also buy one for less than $300.
My first gun was a Ruger MKII semi-auto 22 and it was great for me as I burned lots of ammo and got comfortable with the weapon. I wasn't as budget-limited as you are, so my next was a S&W Model 66 which was great. They are 357 magnum revolvers (they all shoot 38SPL also, but 38s don't shoot 357 mags) that let me switch between easier to shoot inexpensive range ammo and high-powered magnum ammo.
I would go for a S&W, Ruger, Glock, or other higher-end brand of gun so that you will happily own it forever. I own several Taurus pistols and revolvers too. They are less expensive and well-made, although I've had to return my latest for repairs that reflected poor QC. They are also harder to sell for what you have in them than the others.
No matter what you decide, get some training to keep yourself safe and welcome aboard! This is a great bunch of people on THR and you will also find many helpful people at your local range.
JJ