Depends on the season. When I go down to the ranch, the toy chest comes open and I will either take an old favorite or something I have been neglecting. It depends on my mood and what I am planning to do.
During the summer, a 22 for snakes (A 3" S&W 617 works as well as a Ruger Mk 1, 2, or 3). If there are a lot a jack rabbits, a 22 or 22 Mag. In the fall and spring, a 223 for varmints. During deer season, one of my hunting guns. If we are seeing mountain lion sign, a 44 RM Super Blackhawk or a 45 Colt Blackhawk.